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Targets Recommended: Estrogen Receptor/ERR Others

52

抑制剂 & 化合物

3

天然产物

1

化合物库

1888

重组蛋白

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Cat. No.	Product Name
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Target	Signaling Pathways
T11236	Giredestrant tartrate Estrogen receptor antagonist 1	Estrogen Receptor/ERR; Others	Endocrinology/Hormones; Others
	Giredestrant tartrate (Estrogen receptor antagonist 1) 是一种新型的、具有口服活性的、有选择性的、有效的的非甾体雌激素受体拮抗剂。Giredestrant tartrate 与 ER 强效结合，导致 ER 无法激活靶向基因的转录，并促使 ER 蛋白降解。Giredestrant tartrate 可用于治疗肿瘤疾病。
T19649	PF-06273340 PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor	Tyrosine Kinase/Adaptors
	PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。
T24855	TASIN-1 Hydrochloride 塔辛-1盐酸盐,TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl	APC	Cell Cycle/Checkpoint
	TASIN-1 Hydrochloride (TASIN-1 HCl) 是一种截短型 APC 的选择性抑制剂，通过降低细胞胆固醇水平和通过结肠癌细胞中的 ER 应激/ROS/JNK 信号传导诱导凋亡细胞死亡来选择性杀死表达截短型 APC 的结肠直肠癌细胞。
T9266	Fatostatin	Lipid; Fatty Acid Synthase	Metabolism
	Fatostatin A 是一种SREBP 活化的特异性抑制剂，能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性，能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。
T20797	NE-100 hydrochloride NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl	Sigma receptor	GPCR/G Protein
	NE-100 hydrochloride (NE-100 HCl) 是选择性sigma-1 受体拮抗剂，IC50为 4.16 nM。它在体内具有抗精神病活性。它也能抑制内质网应激诱导的海马细胞死亡。
T40130	Nur77 modulator 1 Nur77 modulator 1	Others	Others
	Nur77 modulator 1 可与Nur77结合，KD 为 3.58 μM。它上调 Nur77 表达，介导Nur77亚细胞定位，诱导Nur77 依赖的内质网应激和自噬，可导致细胞凋亡，Nur77 modulator 1显示出抗肝癌生物活性。
T9564	IRE1α kinase-IN-1	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM)，对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化，并抑制 IRE1α RNase 活性 (IC50=80 nM)。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T6509	Galeterone VN-124-1,TOK-001,VN/124-1,VN 124	P450; Androgen Receptor	Endocrinology/Hormones; Metabolism
	Galeterone (VN 124) 是CYP17抑制剂，能够多功能的抗雄激素，在去势抵抗性前列腺癌中，其IC50值为 47 nM。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。
T74857	ER degrader 5
	ER degrader 5 是一种有效的 estrogen receptor(ER)降解剂。ER degrader 5 具有抗增殖活性。ER degrader 5 可以用于乳腺癌研究。
T63675	ER degrader 1
	ER degrader 1 是雌激素受体 (ER) 的有效降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。ER degrader 1 对癌症疾病表现出研究潜力。
T62818	LSD1/ER-IN-1
	LSD1/ER-IN-1 (compound 11g) 是一种有效的 ER 和 LSD1 抑制剂，能够作用于 LSD1 (IC50: 1.55 μM)。LSD1/ER-IN-1 能够高亲和力的选择 Erα 蛋白，α/β 比为 7.11。LSD1/ER-IN-1 对 MCF-7 乳腺癌细胞表现出良好的抗增殖效果 (IC50: 8.79 μM)。
T18696	SNIPER(ER)-110	Others	Others
	SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].
T74221	ER degrader 2
	ER degrader 2 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。ER degrader 2 具有研究癌症疾病的潜力。
T74415	Imlunestrant tosylate
	Imlunestrant (LY-3484356) tosylate 是口服有效且选择性的雌激素受体(estrogen receptor, ER)降解剂(SERD)，具纯拮抗性。该化合物能持续抑制ER依赖的基因转录与细胞生长，适用于研究ER阳性(ER+)晚期乳腺癌(aBC)与子宫内膜样癌(EEC)。
T76417	Yp537 TFA
	Yp537 TFA 是雌激素受体 (ER) 抑制剂，可阻止人类雌激素受体的二聚。
T79382	ER degrader 6	Estrogen Receptor/ERR	Endocrinology/Hormones
	ER degrader 6 (compound 35s) 是高效的雌激素受体 (ER)α降解剂，作用机制为通过抑制微管蛋白聚合破坏微管网络。该化合物能抑制肿瘤生长，并展现出较低的毒性特性。
T74856	ER degrader 4
	ER degrader 4，一种选择性且口服活性的雌激素受体（estrogen receptor）降解剂，展现出抗肿瘤活性。
T18697	SNIPER(ER)-87	Others	Others
	SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
T82450	ER proteostasis regulator-1
	ER proteostasis regulator-1 (化合物481) 是高效的内质网蛋白稳态调节剂，其在阿尔茨海默病与糖尿病研究领域显示出潜在应用价值。
T74222	ER degrader 3
	ER degrader 3 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。ER degrader 3 具有研究癌症疾病的潜力。
T78528	ERX-41	Others	Others
	ERX-41是一种口服活性的立体特异性小分子，靶向溶酶体酸性脂肪酶A (LIPA)。该化合物通过诱导内质网(ER)应激从而导致细胞死亡，这一作用表明ERX-41功能独立于LIPA，但依赖于其在内质网的定位。ERX-41主要用于实体瘤靶向研究。
T63106	Estrogen receptor antagonist 4
	Estrogen receptor antagonist4 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist4 具有研究癌症疾病的潜力。
T18606	PROTAC ER Degrader-2	Others	Others
	PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, exhibits a greater capability to degrade estrogen receptor-alpha (ERα) compared to PROTAC (without the presence of an antibody)[1].
T77985	AZD9496 deacrylic acid phenol	Ligands for Target Protein for PROTAC	PROTAC
	AZD9496脱丙烯酸苯酚是PROTACER Degrader-4的靶蛋白配体片段。
T74593	Taragarestrant meglumine
	Taragarestrant meglumine (D-0502) 是一种口服有效、选择性的雌激素受体 (estrogen receptor) 降解剂，展现了对各种ER+乳腺癌细胞系及移植模型的强大活性。
T61909	Estrogen receptor antagonist 7
	Estrogen receptor antagonist7 (compound 13) 是高效ER拮抗剂，能够抑制乳腺癌细胞与卵巢癌细胞生长，展现出抗癌及抗子宫营养活性。
T14223	Amino-PEG10-amine	Others	Others
	Amino-PEG10-amine is a PEG-based PROTAC linker employed for the conjugation of two mono diethylstilbestrol (DES)-based ligands. This compound offers an alternative approach to the synthesis of highly selective and active ER antagonists, which are crucial for the advancement of endocrine therapy in breast cancer treatment[1].
T75738	Microcystin-RR
	Microcystin-RR (Cyanoviridin RR)，一种有效的口服活性蛋白磷酸酶抑制剂，能诱导细胞凋亡和小鼠肝脏内质网应激。
T78102	ER 50891 quarterhydrate
	ER 50891 quarterhydrate为效效的视黄酸受体α(RARα)拮抗剂，可显著削弱ATRA对BMP 2诱导成骨细胞生成的抑制效果。
T79758	BQZ-485	Apoptosis	Apoptosis
	BQZ-485是一种有效的GDI2抑制剂，它通过与Tyr245相互作用以破坏GDI2-Rab1A之间的内在相互作用，阻断了从内质网(ER)至高尔基体的囊泡转运，并触发了随后的凋亡事件。
T64049	KIRA9
	KIRA9 是 IRE1 的有效抑制剂，对 INS-1 细胞的 IC50 值为 4.8 μM。KIRA9 可以完全结合 IRE1 的 ATP 结合位点，并阻断内质网 (ER) 定位的 mRNA 衰减和细胞凋亡 (apoptosis)。
T61690	mEH-IN-1
	mEH-IN-1 (Compound 62) is a potent inhibitor of microsomal epoxide hydrolase (mEH), with an IC50 value of 2.2 nM. mEH is an α/β-fold hydrolase enzyme that is widely expressed in various mammalian tissues, responsible for the hydrolysis of a diverse range of epoxide-containing molecules. This enzyme is primarily localized in the endoplasmic reticulum (ER) of eukaryotic cells. Research involving mEH-IN-1 can contribute to the understanding of preeclampsia, hypercholanemia, and cancer [1].
T61265	Exo2
	Exo2 is a secretion inhibitor that hinders the trafficking of Shiga toxin from endosomes to the trans-Golgi network. It inhibits the exit of secretory cargo from the endoplasmic reticulum (ER) and disrupts the Golgi apparatus. Notably, Exo2 does not impact the morphology of the trans-Golgi network (TGN). Additionally, Exo2 has the ability to induce calcium-dependent exocytosis in permeabilized adrenal chromaffin cells [1] [2].
T74457	EGFR-IN-42
	EGFR-IN-42 (Compound 17b) 是一种有效的 EGFR 抑制剂，具有单位数纳摩尔活性。EGFR-IN-42 通过共价键将他莫昔芬或安多昔芬与 EGFR 抑制剂吉非替尼连接起来。EGFR-IN-42 保留 ER 拮抗剂活性和 EGFR 抑制作用。EGFR-IN-42 具有优越的抗癌活性。
T79383	ER degrader 7
	ER degrader 7 (Compound 35t) 是一种既能降解ERα又能降解ERβ的化合物。该化合物具有抑制微管蛋白聚合的功能，并能有效降低多种细胞系（包括MCF-7、T47D、MCF-10A、LCC2、T47D D538G与T47D Y537S）的细胞活性，相应IC50s值分别为0.06、2.56、15.84、1.59、1.67、1.37 μM。此外，ER degrader 7 对乳腺癌肿瘤生长同样有抑制作用。
T61755	E6201
	E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
T79359	Anticancer agent 147	Ferroptosis	Apoptosis
	Anticanceragent 147（化合物6j），作为槐定碱的衍生物，功能为铁死亡（Ferroptosis）诱导剂。该化合物能促进Fe2+、活性氧（ROS）及丙二醛（MDA）在细胞内的积累，并通过增加内质网（ER）应激和上调转录因子ATF3的表达发挥作用。在体外及体内实验中，Anticanceragent 147展现了出色的抗肝癌活性。
T78641	ER-27319	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	ER-27319为吖啶酮衍生物，高效选择性抑制SYK，阻断其酪氨酸磷酸化和活性。本化合物阻止抗原刺激下人及大鼠肥大细胞释放过敏介质，IC50约为10 μM，适用于过敏性疾病研究。
T73429	VT02956
	VT02956 是一种LATS 抑制剂 (IC50: LATS1 为 0.76 nM，LATS2 为 0.52 nM)。VT02956 靶向Hippo 信号通路。VT02956 抑制 ER+ 乳腺癌细胞系和患者来源的肿瘤类器官的生长和 ESR1 表达。
T76254L	CD31 TFA
	CD31 TFA（PECAM-1），血小板内皮细胞粘附分子（platelet endothelial cell adhesion molecule-1），是产气荚膜梭菌b-Toxin (CPB)内皮细胞特异性受体，亦为ER-MP12抗原，链接机械应力、代谢与炎症。该肽通过维持CD31 TFA ITIM686与SHP2的磷酸化，抑制TCR诱导的T细胞活化。
T78067	Stobadine (-)-Stobadine	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Stobadine是一种抗氧化剂，能抑制自由基导致的内质网膜流动性变化，可作为基于抗氧化和清除自由基机制的心脏和神经保护剂研发的侯选药物[sup][1]。
T79013	SLMP53-2
	SLMP53-2是一种可以重建p53转录活性的突变p53再激活因子。该化合物通过促进mutp53-Y220C与Hsp70之间的作用，恢复了mutp53-Y220C的野生型构象和其DNA结合能力。此外，SLMP53-2能够诱导细胞周期停滞、细胞凋亡以及ER应激，展现出了其抗肿瘤的潜力。
T76254	CD31
	CD31 (PECAM-1)，一种血小板内皮细胞粘附分子（platelet endothelial cell adhesion molecule-1），兼作产气荚膜梭菌b-Toxin (CPB) 的特异性内皮细胞受体。同时，CD31为ER-MP12抗原，桥接机械应力、代谢与炎症。其肽通过维持CD31 ITIM686与SHP2的磷酸化，抑制TCR诱导的T细胞激活。
T74458	EGFR-IN-43
	EGFR-IN-43 (Compound 17c) 是一种有效的EGFR 抑制剂，具有单位数纳摩尔活性。EGFR-IN-43 通过共价键将他莫昔芬或安多昔芬与EGFR 抑制剂吉非替尼连接起来。EGFR-IN-43 保留 ER 拮抗剂活性和EGFR 抑制作用。EGFR-IN-43 具有优越的抗癌活性。
T74891	Apratoxin S4
	Apratoxin S4（Apra S4）是一种Sec61抑制剂，能够有效阻止分泌蛋白的共翻译转运进入内质网(ER)。它对flaviviruses类病毒显示出抗病毒效果，IC50值在0.46 nM至170 nM不等。此外，Apratoxin S4通过抑制多条血管生成通路，能够抑制视网膜血管细胞活化，适用于病毒感染、血管生成相关疾病和癌症的研究。
T78007	Vasonatrin Peptide (VNP) TFA
	Vasonatrin Peptide (VNP) TFA 是一种由心钠素 (ANP) 和C型利钠肽 (CNP) 嵌合而成的肽类化合物。它整合了CNP的静脉扩张功能、ANP的利尿效果，并展现出与ANP或CNP无关的特有动脉扩张特性。Vasonatrin Peptide TFA 透过cGMP-PKG信号途径发挥其对内质网应激介导的糖尿病心脏缺血再灌注损害的保护作用。
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...
T35578	Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre...

化合物

Giredestrant tartrate

Cat.No: T11236

Synonym: Estrogen receptor antagonist 1

Target: Estrogen Receptor/ERR, Others

Cat.No: T19649

Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340

Target: Trk receptor

TASIN-1 Hydrochloride

Cat.No: T24855

Synonym: 塔辛-1盐酸盐,TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl

Target: APC

Cat.No: T9266

Target: Lipid, Fatty Acid Synthase

NE-100 hydrochloride

Cat.No: T20797

Synonym: NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl

Target: Sigma receptor

Nur77 modulator 1

Cat.No: T40130

Synonym: Nur77 modulator 1

Target: Others

IRE1α kinase-IN-1

Cat.No: T9564

Target: IRE1

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

Cat.No: T6509

Synonym: VN-124-1,TOK-001,VN/124-1,VN 124

Target: P450, Androgen Receptor

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Cat.No: T74857

Cat.No: T63675

Cat.No: T62818

Cat.No: T18696

Target: Others

Cat.No: T74221

Imlunestrant tosylate

Cat.No: T74415

Cat.No: T76417

Cat.No: T79382

Target: Estrogen Receptor/ERR

Cat.No: T74856

Cat.No: T18697

Target: Others

ER proteostasis regulator-1

Cat.No: T82450

Cat.No: T74222

Cat.No: T78528

Target: Others

Estrogen receptor antagonist 4

Cat.No: T63106

PROTAC ER Degrader-2

Cat.No: T18606

Target: Others

AZD9496 deacrylic acid phenol

Cat.No: T77985

Target: Ligands for Target Protein for PROTAC

Taragarestrant meglumine

Cat.No: T74593

Estrogen receptor antagonist 7

Cat.No: T61909

Amino-PEG10-amine

Cat.No: T14223

Target: Others

Cat.No: T75738

ER 50891 quarterhydrate

Cat.No: T78102

Cat.No: T79758

Target: Apoptosis

Cat.No: T64049

Cat.No: T61690

Cat.No: T61265

Cat.No: T74457

Cat.No: T79383

Cat.No: T61755

Anticancer agent 147

Cat.No: T79359

Target: Ferroptosis

Cat.No: T78641

Target: Syk

Cat.No: T73429

Cat.No: T76254L

Cat.No: T78067

Synonym: (-)-Stobadine

Target: Reactive Oxygen Species

Cat.No: T79013

Cat.No: T76254

Cat.No: T74458

Cat.No: T74891

Vasonatrin Peptide (VNP) TFA

Cat.No: T78007

Cat.No: T36570

Phosphatidylserines (sodium salt)

Cat.No: T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

Cat. No.	Product Name	Target	Signaling Pathways
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
T75540	Ipomoeassin F
	Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂，它通过作用于ER膜上的Sec61复合物（Sec61α）的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位，同时阻碍分泌蛋白和I型跨膜蛋白（TMP）的ER转运，但对III型TMP的转运不产生影响。
T75622	β-Apopicropodophyllin
	β-Apopicropodophyllin 是一种天然产物，可以从Hyptis wticillata 中分离得到。β-Apopicropodophyllin 通过诱导微管破坏、DNA 损伤、细胞周期停滞和 ER 应激来诱导细胞凋亡。β-Apopicropodophyllin 可用于癌症研究。

天然产物

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Cat.No: T75540

β-Apopicropodophyllin

Cat.No: T75622

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00762	ER alpha Protein, Human, Recombinant (His) Estrogen Receptor,ER α,estrogen receptor α,ER	Human	E. coli
	Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as ...
TMPJ-01384	MAN1B1 Protein, Human, Recombinant (His) ER Alpha-1,Man9...	Human	Human Cells
	Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation i...
TMPJ-01229	SUMF1 Protein, Human, Recombinant (His) C-Alpha-Formylglycine-Genera<...	Human	Human Cells
	Human Sulfatase Modifying Factor 1 (SUMF1) is a 42kDa protein. SUMF1 is a Ca2+-binging member of the sulfatase-modifying factor family. SUMF1 is a soluble ER lumenal glycoprotein, it converts inactive sulfatases into an active form by transforming a catalytic site cysteine into a formylglycine residue. In the ER, SUMF1 can exist as either a monomer, or a disulfide-linked homodimer or a heterodimer with SUMF2. Three splice isoforms are known.
TMPK-00074	IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) IFN-α-1/13,IFN alpha...	Mouse	HEK293
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
TMPK-00075	IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) IFN-α-1/13,IFN α1,IFN al...	Human	HEK293
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
TMPY-02890	ERP27 Protein, Human, Recombinant (mFc) endoplasmic reticulum protein 27,C12orf46,...	Human	HEK293
	ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartmen...
TMPJ-00919	FKBP2 Protein, Human, Recombinant (His) also named 13 kDa FK506-...	Human	Human Cells
	Peptidyl-prolyl cis-trans isomerase FKBP2(FKBP2 for short), also named 13 kDa FK506-binding protein, FK506-binding protein 2, Immunophilin FKBP13, Rotamase, is a endoplasmic reticulum peripheral membrane protein. It contains 1 PPIase FKBP-type domain and belongs to the FKBP-type PPIase family, FKBP2 subfamily which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 an...
TMPJ-01404	TMX2 Protein, Human, Recombinant (His) Cell proliferation-inducing gene 26 protei...	Human	E. coli
	TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The Molecular Cloning and characterization of one member of the thioredoxin superfamily, designated as TMX2.The TMX2 cDNA consists of 1644 nucleotides and contains an open reading frame encoding a protein of 372 amino acids with a predicted molecular mass of 42.5 kDa and an isoelectric point of 8.94. The TMX2 protein may pos...
TMPJ-00246	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) MK,CD262,Tnfrsf10b,Dr5,Tumor necrosis fact...	Mouse	Human Cells
	Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ...
TMPY-04422	Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His) CK1g2,casein kinase 1, γ...	Human	Baculovirus-Insect Cells
	Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...
TMPJ-00245	TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (Avi & His), Biotinylated Dr5,CD262,Death receptor 5,Tnfrsf10b,Kill<...	Mouse	Human Cells
	Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ...
TMPY-01769	4EBP1 Protein, Human, Recombinant (His) 4E-BP1,eukaryotic transla	Human	E. coli
	The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, a...
TMPY-01156	ULBP-1 Protein, Human, Recombinant (His) UL16 binding protein 1,RAET1<...	Human	HEK293
	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins, and have tissue-specific expressions. ULBP1, also known as RAET1I and NKG2DL1, together with at least ULBP 2 and 3, are well-known ligands for NKG2D, and activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemok...
TMPY-05591	ULBP-1 Protein, Human,Recombinant(aa 1-216, His&AVI),Biotinylated RAET1I,UL16 binding protein 1...	Human	HEK293
	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins, and have tissue-specific expressions. ULBP1, also known as RAET1I and NKG2DL1, together with at least ULBP 2 and 3, are well-known ligands for NKG2D, and activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemok...
TMPY-01405	ULBP-1 Protein, Human, Recombinant (His & hFc) UL16 binding protein 1,RAET1<...	Human	HEK293
	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins, and have tissue-specific expressions. ULBP1, also known as RAET1I and NKG2DL1, together with at least ULBP 2 and 3, are well-known ligands for NKG2D, and activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemok...
TMPJ-01212	ULBP-1 Protein, Mouse, Recombinant (His) RAET1I,ULBP1,NKG2DL1	Mouse	Human Cells
	Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or inte...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) CD3-DELTA,CD3d molecule, delta (CD3-TCR co...	Human	HEK293
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1
TMPY-00664	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc) Angiopoietin-2,AGPT2,angiopoietin...	Human	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 mod...
TMPY-01298	CADM1 Protein, Human, Recombinant (His) Necl-2,cell adhesion molecule 1,SYNCA<...	Human	HEK293
	Members of the immunoglobulin superfamily often play key roles in intercellular adhesion. IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Three Ig-like domains are included in the extracellular domain of IGSF4 and mediate homophilic or heterophilic interactions independently of Ca2+. The cytoplasmic domain of IGSF4 contains the binding motifs that connect to actin fibers. Since IGSF4 has been characterized by several independent research groups, this molecule is called...
TMPY-04779	BTN3A2 Protein, Human, Recombinant (His) BTF3,BT3.2,BTF4,BTN3.2,CD277,butyrophilin subfamily...	Human	HEK293
	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted...
TMPY-03363	C-Reactive Protein Protein, Human, Recombinant C-Reactive Protein,C-reactive protein, pen...	Human	HEK293
	C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monit...
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant PD1,α-Synuclein,PARK4,synuclein, α (non	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the...
TMPY-05354	CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated CD28 molecule,Tp44	Human	HEK293
	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell r...
TMPY-00586	CLEC-2 Protein, Mouse, Recombinant (hFc) 1810061I13Rik,Clec2,C-ty...	Mouse	HEK293
	CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and...
TMPY-04824	CTLA-4 Protein, Human, Recombinant CTLA-4,GSE,IDDM12,CELIAC3,A	Human	HEK293
	Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role i...
TMPY-00986	IL-34 Protein, Mouse, Recombinant (His) interleukin 34,2010004A03Rik,...	Mouse	HEK293
	IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R). IL-34 protein is expressed in various tissues, including heart, brain, lung, liver, kidney, spleen, thymus, testes, ovary, small intestine, prostate, and colon, and most abundant in the spleen. The colon...
TMPY-03273	IL-18 Protein, Mouse, Recombinant interleukin 18,白细胞介素,白介素,Il-18,Ig...	Mouse	E. coli
	Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-02412	ENO1 Protein, Human, Recombinant (His) PPH,NNE,enolase 1, (alpha	Human	E. coli
	The ENO1 gene encodes a multifunctional enzyme that has been identified as a key component of the glycolytic pathway. ENO1 overexpression and post-translational modifications could be of diagnostic and prognostic value in many cancer types. The results of the ENO1 expression profiling of ovarian follicles suggest that ENO1 may play an important dual role in the progress of follicular development, where ENO1 acts as a glycolytic enzyme and also mediates apoptosis. ENO1 overexpression could make ...
TMPY-01055	IL-4R Protein, Human, Recombinant (His) interleukin 4 receptor,IL4RA,IL4R,CD1<...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-01912	Cadherin 17/CDH17 Protein, Human, Recombinant (His) HPT-1,cadherin 17, LI c<...	Human	HEK293
	Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of ...
TMPY-01834	CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His) CD16,Fc receptor, IgG, low affinity III	Mouse	HEK293
	Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as...
TMPY-01608	Decorin Protein, Human, Recombinant (His) PGS2,PG40,CSCD,decorin,SLRR1B,DSPG2,PGII	Human	HEK293
	Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role...
TMPY-00843	IL-25/IL17E Protein, Human, Recombinant (hFc) interleukin 25,IL17E	Human	HEK293
	Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–produ...
TMPY-05277	IL-4R Protein, Human, Recombinant (hFc) IL4R,IL4RA,CD124,IL-4RA,inter...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-04810	CD47 Protein, Mouse, Recombinant (His) AA407862,CD47 molecule,AW1	Mouse	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b...
TMPY-01280	FOLR2 Protein, Human, Recombinant (His) FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2...	Human	HEK293
	Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc...
TMPY-01462	IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) interleukin 11 receptor subunit <...	Human	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increas...
TMPY-03256	NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His) KLR,killer cell lectin-like receptor subfa...	Human	Baculovirus-Insect Cells
	KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stim...
TMPY-05579	PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated PRR1,ED4,PVRR,nectin-1,OFC7,SK-12...	Human	HEK293
	Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of ...
TMPY-00939	Thrombopoietin Protein, Mouse, Recombinant (His) thrombopoietin,Mpllg,Tpo,Mgdf,Ml	Mouse	HEK293
	Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin...
TMPY-05435	ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) angiopoietin 1,AGPT,AGP<...	Human	HEK293
	The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures...
TMPY-03762	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) cadherin 1, type 1, E-c<...	Human	HEK293
	Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lo...
TMPY-01431	L1CAM Protein, Human, Recombinant (His) N-CAM-L1,MASA,HSA	Human	HEK293
	L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif ...
TMPY-01701	IL-12RB1 Protein, Human, Recombinant (His) interleukin 12 receptor, β1,IL	Human	HEK293
	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity and is thought to be a part of the IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 bind...
TMPY-01907	VSIG4 Protein, Human, Recombinant (His) Z39IG,CRIg,V-set and immunoglobulin domain...	Human	HEK293
	VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that a...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His) CRISTIN1,THSD2,R-spondin 3,PWTSR	Human	HEK293
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s...
TMPY-04793	IL-35 Protein, Human, Recombinant (Flag & His) NKSF1,P35,白介素,Interleukin-35,CLMF,白细胞介素,NF...	Human	HEK293
	IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is required for the T-cell-independent induction of IFN-gamma and is important for the differentiation of both Th1 and T...
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重组蛋白

ER alpha Protein, Human, Recombinant (His)

Cat.No: TMPJ-00762

Species: Human

Expression System: E. coli

MAN1B1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01384

Species: Human

Expression System: Human Cells

SUMF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01229

Species: Human

Expression System: Human Cells

IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00074

Species: Mouse

Expression System: HEK293

IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00075

Species: Human

Expression System: HEK293

ERP27 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-02890

Species: Human

Expression System: HEK293

FKBP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00919

Species: Human

Expression System: Human Cells

TMX2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01404

Species: Human

Expression System: E. coli

TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00246

Species: Mouse

Expression System: Human Cells

Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04422

Species: Human

Expression System: Baculovirus-Insect Cells

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00245

Species: Mouse

Expression System: Human Cells

4EBP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01769

Species: Human

Expression System: E. coli

ULBP-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01156

Species: Human

Expression System: HEK293

ULBP-1 Protein, Human,Recombinant(aa 1-216, His&AVI),Biotinylated

Cat.No: TMPY-05591

Species: Human

Expression System: HEK293

ULBP-1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-01405

Species: Human

Expression System: HEK293

ULBP-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01212

Species: Mouse

Expression System: Human Cells

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-03745

Species: Human

Expression System: HEK293

ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00664

Species: Human

Expression System: HEK293

CADM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01298

Species: Human

Expression System: HEK293

BTN3A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04779

Species: Human

Expression System: HEK293

C-Reactive Protein Protein, Human, Recombinant

Cat.No: TMPY-03363

Species: Human

Expression System: HEK293

Alpha-Synuclein Protein, Human, Recombinant

Cat.No: TMPY-02512

Species: Human

Expression System: E. coli

CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05354

Species: Human

Expression System: HEK293

CLEC-2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00586

Species: Mouse

Expression System: HEK293

CTLA-4 Protein, Human, Recombinant

Cat.No: TMPY-04824

Species: Human

Expression System: HEK293

IL-34 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00986

Species: Mouse

Expression System: HEK293

IL-18 Protein, Mouse, Recombinant

Cat.No: TMPY-03273

Species: Mouse

Expression System: E. coli

ENO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02412

Species: Human

Expression System: E. coli

IL-4R Protein, Human, Recombinant (His)

Cat.No: TMPY-01055

Species: Human

Expression System: HEK293

Cadherin 17/CDH17 Protein, Human, Recombinant (His)

Cat.No: TMPY-01912

Species: Human

Expression System: HEK293

CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)

Cat.No: TMPY-01834

Species: Mouse

Expression System: HEK293

Decorin Protein, Human, Recombinant (His)

Cat.No: TMPY-01608

Species: Human

Expression System: HEK293

IL-25/IL17E Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00843

Species: Human

Expression System: HEK293

IL-4R Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05277

Species: Human

Expression System: HEK293

CD47 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04810

Species: Mouse

Expression System: HEK293

FOLR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01280

Species: Human

Expression System: HEK293

IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)

Cat.No: TMPY-01462

Species: Human

Expression System: HEK293

NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)

Cat.No: TMPY-03256

Species: Human

Expression System: Baculovirus-Insect Cells

PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05579

Species: Human

Expression System: HEK293

Thrombopoietin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00939

Species: Mouse

Expression System: HEK293

ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05435

Species: Human

Expression System: HEK293

E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03762

Species: Human

Expression System: HEK293

L1CAM Protein, Human, Recombinant (His)

Cat.No: TMPY-01431

Species: Human

Expression System: HEK293

IL-12RB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01701

Species: Human

Expression System: HEK293

VSIG4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01907

Species: Human

Expression System: HEK293

R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)

Cat.No: TMPY-02115

Species: Human

Expression System: HEK293

IL-35 Protein, Human, Recombinant (Flag & His)

Cat.No: TMPY-04793

Species: Human

Expression System: HEK293

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